Everyone is less than enthusiastic when Sullivan assigns each member of the crew a specialty skill to learn. During a house call, Ryan is caught off guard when he comes face-to-face with someone from his past; and Sullivan, Andy and Maya handle a structure fire in a derelict building.

As Adina starts the next stage of her plan, astronauts Juliet and Richard see warning signs in space; uncovering Adina's sinister mission.

With Richard's help, Catherine discovers she can travel to another world; a new revelation puts Martha's loyalties to the test; Zoe breaks Bill out of prison.

M.O.D.O.K., finding himself stifled by GRUMBL’s bureaucratic control of AIM, teams up with Monica to take down their new bosses. Monica's hatred toward M.O.D.O.K. remains, however, and she ends up betraying M.O.D.O.K., causing the two to have a mad scientist duel, which M.O.D.O.K. loses in front of his whole company. Monica is promoted to Scientist Supreme and M.O.D.O.K. is stripped of his authority. Meanwhile, Jodie's life without M.O.D.O.K. flourishes as one of her videos goes viral, launching her into internet fame.

M.O.D.O.K., finding himself stifled by GRUMBL’s bureaucratic control of AIM, teams up with Monica to take down their new bosses. Monica's hatred toward M.O.D.O.K. remains, however, and she ends up betraying M.O.D.O.K., causing the two to have a mad scientist duel, which M.O.D.O.K. loses in front of his whole company. Monica is promoted to Scientist Supreme and M.O.D.O.K. is stripped of his authority. Meanwhile, Jodie's life without M.O.D.O.K. flourishes as one of her videos goes viral, launching her into internet fame.

Lou, feeling like M.O.D.O.K. is stifling his individuality ahead of his bar mitzvah, jumps into M.O.D.O.K.’s portal to Asgard. There, Lou is taken by a tribe of goblins known as Kobolds, but wins them over with his magic tricks and becomes their leader. He refuses to go back home with his dad, so M.O.D.O.K. takes control of an army of Asgardian warriors and wages war against his son. Eventually, M.O.D.O.K. and Lou strike a deal and use Lou's magic tricks to pacify the Kobolds. Meanwhile, the Super Adaptoid agrees to help young M.O.D.O.K.

With Richard's help, Catherine discovers she can travel to another world; a new revelation puts Martha's loyalties to the test; Zoe breaks Bill out of prison.

Bailey and April work to fix things between Richard and Catherine. Meanwhile, Eliza continues to pursue Arizona, and one of Alex's previous patients returns to Grey Sloan.

April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers.

Gabrielle struggles with the reality of having a blind husband. Lynette is surprised when Rick Coletti shows up at the Scavo pizzeria. Bree and Katherine join forces to plan the Founders Day Ball. As part of his recovery, Mike asks a few people for forgiveness, and Orson starts sleepwalking.

Bree and Katherine decide to start a catering business together. Lynette tries to deny her feelings for Rick. Mike learns the truth about his nearly fatal accident. Carlos gets a seeing-eye dog. Dylan meets her estranged father.

On National Nurses' Day, Chastain's nurses are severely understaffed and overworked, leaving them all feeling exhausted and underappreciated. Cain performs a dangerous surgery on a new patient he won in a game of poker. Meanwhile, Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death, The Raptor comes face-to-face with his birth mother for the first time and Irving attempts to take the next step in his relationship with Jessica.

Bailey and April work to fix things between Richard and Catherine. Meanwhile, Eliza continues to pursue Arizona, and one of Alex's previous patients returns to Grey Sloan.

April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers.

Gabrielle struggles with the reality of having a blind husband. Lynette is surprised when Rick Coletti shows up at the Scavo pizzeria. Bree and Katherine join forces to plan the Founders Day Ball. As part of his recovery, Mike asks a few people for forgiveness, and Orson starts sleepwalking.

Bree and Katherine decide to start a catering business together. Lynette tries to deny her feelings for Rick. Mike learns the truth about his nearly fatal accident. Carlos gets a seeing-eye dog. Dylan meets her estranged father.

The Chastain staff works together to diagnose a mother-daughter pair who both come in with symptoms that make it difficult to determine their conditions. Devon deals with an unexpected visit from his mother and Conrad and Nic try to figure out the best time to tell everyone their big news. Meanwhile, Bell deals with an over-eager fan of his show who ends up needing treatment at Chastain and Mina makes a bold move when she realizes her visa is about to expire.

When one of Chastain's own is brought into the emergency room with life-threatening injuries, the staff rallies around each other to try to save her life, while disagreements over how to best handle her care put Cain at odds with the rest of the doctors. Also, Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention. Meanwhile, Conrad turns heads when he shares data about Hemopleatin, and Kyle begins volunteering at the hospital.

The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news that pushes Amelia to step up to support him, and Alex attends a medical conference after making a shocking discovery.

Alex must make a hard decision in his relationship with Jo, while Meredith has some news for Riggs that brings their relationship to a turning point.

Susan meets her ex-husband, Karl at a Lamaze class, and finds out that he has remarried and is having another child. Lynette learns who was responsible for starting the fire at Rick's restaurant. Bree wants Orson to turn himself in to the police. Meanwhile, Gabrielle rents a room to a hip artist, Ellie, who has a dark secret. Elsewhere, Dylan continues meeting with her father, Wayne, and Katherine decides to go spy on her.

Adele Delfino, Susan's mother-in-law, arrives for a visit. Carlos and Gabrielle find out their tenant, Elli, has a dark secret. A full scale war erupts between Bree and Edie.

Everyone is less than enthusiastic when Sullivan assigns each member of the crew a specialty skill to learn. During a house call, Ryan is caught off guard when he comes face-to-face with someone from his past; and Sullivan, Andy and Maya handle a structure fire in a derelict building.

Megan & Tommy investigate the murder of a young woman, which leads them to her neighbor, who bites Tommy and is diagnosed with rabies. When another rabies fatality comes in without any bite, Kate calls in the new health commissioner to help Megan.

Kate meets Sergei, a handsome and mysterious guest at a political event, and is irresistibly drawn to him. But when a young Russian girl is found murdered near the hotel where she and Sergei are having a tryst, Kate suspect and turns to Megan for help.

The Chastain staff works together to diagnose a mother-daughter pair who both come in with symptoms that make it difficult to determine their conditions. Devon deals with an unexpected visit from his mother and Conrad and Nic try to figure out the best time to tell everyone their big news. Meanwhile, Bell deals with an over-eager fan of his show who ends up needing treatment at Chastain and Mina makes a bold move when she realizes her visa is about to expire.

Rosewood and Villa are pulled into the world of human trafficking to investigate the death of a school teacher, and a surprising insight into Slade’s past draws Rosie and Villa closer than ever before.

Miami pathologist, Dr. Beaumont Rosewood, Jr., finds secrets in people's bodies using his state-of-the-art laboratory equipment.

The Chastain staff works together to diagnose a mother-daughter pair who both come in with symptoms that make it difficult to determine their conditions. Devon deals with an unexpected visit from his mother and Conrad and Nic try to figure out the best time to tell everyone their big news. Meanwhile, Bell deals with an over-eager fan of his show who ends up needing treatment at Chastain and Mina makes a bold move when she realizes her visa is about to expire.

Everyone is less than enthusiastic when Sullivan assigns each member of the crew a specialty skill to learn. During a house call, Ryan is caught off guard when he comes face-to-face with someone from his past; and Sullivan, Andy and Maya handle a structure fire in a derelict building.

Susan meets her ex-husband, Karl at a Lamaze class, and finds out that he has remarried and is having another child. Lynette learns who was responsible for starting the fire at Rick's restaurant. Bree wants Orson to turn himself in to the police. Meanwhile, Gabrielle rents a room to a hip artist, Ellie, who has a dark secret. Elsewhere, Dylan continues meeting with her father, Wayne, and Katherine decides to go spy on her.

Adele Delfino, Susan's mother-in-law, arrives for a visit. Carlos and Gabrielle find out their tenant, Elli, has a dark secret. A full scale war erupts between Bree and Edie.

The Grey Sloan doctors treat a patient who encountered illegal fireworks. Bailey has her sights set on hiring new doctors, but she's having trouble finding viable options. Owen and Teddy attempt to take the next step in their engagement.

Meredith seeks advice from Amelia. Richard is re-energized as he takes teaching to a new level at the hospital. Winston treats a patient suffering from kidney failure.

Upon dubbing Thanksgiving “the most dangerous day of the year,” Devon and Irving are inundated with patients in the ER. When an A-list celebrity enters the hospital after swallowing a wish bone, Logan Kim assigns a new surgeon to the case in the hopes of garnering extra publicity.