The residents of Wisteria Lane finally learn Martha Huber's fate. After learning that Mrs. Huber left behind a journal, Susan is forced to confess to Edie about her role in the fire that burned down Edie's house. Meanwhile Bree finds her new beau, George getting a little too close for comfort. Lastly, Carlos returns, but his homecoming isn't quite what Gabrielle had in mind. He is under house arrest, making it difficult for either of them to make money.

With Adina's plan for world destruction reaching completion, and our heroes in the alternate world under attack, both sides must make great sacrifices if they are to save humanity.

With Adina's plan in motion, the world's last hope is for Bill to make one more journey, risking his own life in search of Catherine's help.

Woohoo! School's out, so the Solars make a splash at summer camp!

Korvo and Terry place nanobots in the city's water supply to spy on their neighbors. Learning they are not well-liked, Korvo and Terry use the information from the nanobots to win over the community, and run for president of their homeowner association. The nanobots form a sentient person that runs for president as well, and all three expose embarrassing secrets about their neighbors, who break out in violence. The incumbent president Ruth restores order and turns the crowd against Korvo, Terry, and the nanobot person, who escapes from Korvo. Jesse – concerned that Yumyulack is shrinking and capturing too many humans – uses technology to manipulate people who were mean to Yumyulack, hoping to teach him that humans are generally kind.

Catherine, Sophia, Zoe and the other survivors, finally reunited, prepare for the ultimate attack. But it is Bill who is the only one to hold the destiny of humanity in his hands, provided he is helped by Isla.

As people across the globe are experiencing hallucinations, MI5 agent Zoe contacts Bill for answers; Catherine Durand detects unusual black hole activity.

As Adina starts the next stage of her plan, astronauts Juliet and Richard see warning signs in space; uncovering Adina's sinister mission.

As Conrad battles a group of overly aggressive attending physicians on behalf of a patient with a mysterious chronic ailment, he also must face off against his father who has shown up at the hospital unannounced.

Conrad goes head-to-head with Lane when he disagrees with her over a treatment plan for a terminal cancer patient. Tensions rise when Jude inserts himself in the middle by offering to perform the invasive procedure Conrad is fighting against. When a VIP patient crosses the line with Nic, she must devise a strategy on how to stand her ground and combat the situation. Meanwhile, Bell realizes he'll need Mina's hands more than ever.

Much to Bell's dismay, Nic and Conrad decide to admit a homeless Jane Doe, whom they suspect was dumped off by another hospital during Chastain's big Charity Ball. Devon and Irving care for a male escort who offers surprisingly good advice.

Dr. Addison Forbes Montgomery returns and graces the Grey Sloan halls with her experience and expertise as she attempts to help Richard teach the newest crop of residents. Meredith has a decision to make; Link confides in Teddy.

Richard recruits Meredith and Bailey to help him launch a new program. Addison's patient has complications from a procedure. Jo helps a woman who goes into premature labor.

The doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

Andy, Sullivan, Dean and Ben are faced with a tough choice while trying to save a couple trapped in their car. Travis' dad fears he will be outed when his "golfing friend" is exposed to COVID-19.

Maya, Jack, Vic, Travis and Sullivan respond to a burn call at an ice rink. Meanwhile, a pregnant woman and her husband seek out the station for help; and Maya and Carina have a difficult conversation.

The women decide to go ahead with the big dinner party that the late Mary Alice Young had planned to host, despite the more-than-minor disturbances in their own lives. Adulterous Gabrielle finds herself with a nine-year-old blackmailer who catches Gabrielle in the act in her affair with gardener John. Also, Bree struggles to keep her crumbling marriage a secret. Lastly, Susan bares all--in more ways than one--as she confronts her ex.

Cash-strapped Mrs. Huber figures out that Susan had something to do with Edie's house fire and tries to blackmail her. Meanwhile, Carlos becomes suspicious that Gabrielle is seeing another man, but targets the wrong suspect---the cable guy instead of gardener John. Also, Lynette balks when the twins' teacher insists the boys have ADD but tries to salvage the matter by seprating the boys. Lastly, Bree struggles with her rebellious son Andrew after Rex moves out.

A break-in on Wisteria Lane leaves the neighbors feeling vulnerable, especially Susan, who reluctantly accepts a date with a persistent policeman after Mike appears indifferent to her. Rex takes the kids away for the weekend as a lonely Bree finds herself bonding with Zach. Meanwhile, Lynette and Tom pull out all the stops to get their uncontrollable twins Porter and Preston accepted at a prestigious private school, and the unexpected arrival of Carlos' mother puts a crimp in Gabrielle's covert love life.

Dr. Megan Hunt was in a class of her own, a brilliant neurosurgeon at the top of her game. Her world is turned upside down when a devastating car accident puts an end to her time in the operating room. Megan resumes her career as a medical examiner determined to solve the puzzle of who or what killed the victims.

A rock and roll enthusiast expands his love to living teens by tormenting them into stealing. Melinda must also deal with the ghost of her scheming ex-boyfriend.

Crew week on The Odyssey sends Max back to his hometown for answers; Tristan reveals Avery's secret to Vivian; Munroe fights a parasitic infection; Avery pressures Rosie to face a medical condition she's been hiding.

A plane crashes in Philadelphia due to a gunman opening fire while aloft. The crash hits the city's main power grid, Megan must conduct autopsies on the victims during frequent blackouts, but then one of the bodies goes missing.

An inmate violently escapes from a prison transport van. Then a witness in the escaped prisoner's murder trial is found dead. The accused murderer shows up and pleads with Megan that he is innocent and being framed.

Megan probes more deeply into her father's suicide so much that she finally gets some closure.

In the aftermath of tragedy with Bree's son Andrew running over Carlos' mother Juanita Solis, the residents of Wisteria Lane take stock of their lives. Meanwhile, Susan grows suspicious of Mike's real reason for moving to the street. Lynette reaches the breaking point in her addiction to the twins' ADD medication as she tries other measures like acupuncture to release her stress. The mysterious Mr. Shaw gets down to business as he develops a relationship with Edie. Lastly, Gabrielle confesses her adulterous affair to a priest while

Looking to give her life a purpose, Gabrielle decides to organize a glamorous Halston fashion show for charity highlighting the ladies of Wisteria Lane. Bree and Rex are at odds on how to punish Andrew for putting Mrs. Solis in the hospital and finding drugs in his room. The police investigate a toy chest that Paul Young dumped in the river. Lastly, Lynette uses her business acumen to poach a nanny, Claire, but ends up getting involved between her current employer, Alexis.

Uber mom Maisy Gibbons returns, and her secret life intersects with Bree's. Meanwhile Gabrielle's predicament worsens as she gets a taste of her own medicine, courtesy of Carlos's jailhouse confession. Susan plans to take her relationship with Mike to the next level, and Lynette, suspicious (and a little jealous) of her new nanny decides to secretly videotape her. Lastly, Susan sends Zach Young back home to his father, who makes a startling admission of his own.

A plane crashes in Philadelphia due to a gunman opening fire while aloft. The crash hits the city's main power grid, Megan must conduct autopsies on the victims during frequent blackouts, but then one of the bodies goes missing.

An inmate violently escapes from a prison transport van. Then a witness in the escaped prisoner's murder trial is found dead. The accused murderer shows up and pleads with Megan that he is innocent and being framed.

Nick whisks Meredith away to his Minnesota cabin for a romantic weekend, leaving Winston and Maggie to care for Meredith’s children. Meanwhile, Amelia and Kai grow closer.

As Conrad battles a group of overly aggressive attending physicians on behalf of a patient with a mysterious chronic ailment, he also must face off against his father who has shown up at the hospital unannounced.

Conrad goes head-to-head with Lane when he disagrees with her over a treatment plan for a terminal cancer patient. Tensions rise when Jude inserts himself in the middle by offering to perform the invasive procedure Conrad is fighting against. When a VIP patient crosses the line with Nic, she must devise a strategy on how to stand her ground and combat the situation. Meanwhile, Bell realizes he'll need Mina's hands more than ever.

Much to Bell's dismay, Nic and Conrad decide to admit a homeless Jane Doe, whom they suspect was dumped off by another hospital during Chastain's big Charity Ball. Devon and Irving care for a male escort who offers surprisingly good advice.