Andy and Sullivan's relationship continues to be tested. Meanwhile, Emmett joins Dean and Vic on a mental health call, and Maya does some soul searching.

London, four months after the attack. The survivors organize the Resistance. Bill continues his research on aliens and understands that their DNA is human but that their organs are degenerating. In France, a severely wounded dissident alien reaches the Observatory

At the Observatory, Mokrani and Catherine clash over the fate to be reserved for Micah, whom Catherine considers to be a major source of information. Micah reveals to Catherine that she has to find Bill Ward. The latter, for his part, tries to find out more about Emily, still assailed by visions of Adina, the leader of the aliens urging him to kill Bill.

One year after escaping the destruction of their planet Shlorp and crashing on Earth, aliens Korvo, Terry, and their child-replicants Yumyulack and Jesse adjust to their new lives. Korvo is determined to repair their spaceship, but Terry introduces him to the television show Funbucket. Realizing that the titular alien is fictional, they create a real Funbucket, who tires of them and befriends humans Travis and Avery. Forced to attend high school, Yumyulack and Jesse are menaced by their classmates and faculty. They shrink a bully named Lydia, hoping to use her to study human behavior. As the Shlorpian family have dinner together, it is revealed that their pet, the Pupa, will one day evolve and destroy Earth to terraform a new Shlorp.

Super villain M.O.D.O.K. runs his evil organization AIM into the ground and is forced to sell it to the tech company GRUMBL. As the megalomaniacal M.O.D.O.K. struggles to regain control of AIM, he risks losing something even more important…his family!

Inside the Wall, Tim – imprisoned and tortured on the Duke's orders – is convinced by his cellmate Jean-Pierre to write letters calling for revolution. They are rescued by Cherie and her fellow rebels, and prepare to overthrow the Duke. Tim and Cherie spend a passionate night together, and copies of Tim's letters spread throughout the Wall, drawing people to their cause; Cherie urges Tim to lead them. As the Duke addresses a congregation, his sheriff spots Tim in the crowd and attacks, killing Jean-Pierre. Tim unites the oppressed inhabitants of the Wall in an open rebellion. The Duke floods the lower levels, drowning countless people; a farmer named Steven is unable to save his beloved mouse, Molly.

When astrophysicists detect a transmission from another galaxy, it is definitive proof of intelligent extra-terrestrial life. The world's population waits for further contact with baited breath. They do not have to wait long. Within days, mankind is all but wiped out; just pockets of humanity are left in an eerily deserted world.

A former patient of Link's, named Simon, is in the emergency room with his pregnant wife. Bailey receives an offer from Nick.

A dinner party is thrown at the sister house in Nick's honor; Grey Sloan Memorial receives a victim of a brutal hate crime.

The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.

Susan's mom pays an unannounced visit to Wisteria Lane after she and her boyfriend call it quits. Meanwhile, Gabrielle faces Carlos' wrath after he learns about the hospital settlement and tries to change their prenuptial agreement in order to keep Gabrielle in check while he serves his jail sentence. Lynette and Bree experience a chill in their friendship after Bree babysits Lynette's kids and dares to discipline Porter. Also, Bree and Rex visit Andrew at the teen rehab camp where they learn some shocking news about their son. Lastly, Felicia gets closer to Zach and reveals some disturbing details about his family in the past.

Devon and Conrad race against the clock to save the life of a woman who is deteriorating fast from undetermined symptoms. When the patient turns out to be a hero who helps previous criminals get their lives back together, the team relies on her family of ex-cons to help diagnose and treat her. Tensions rise as Nic continues her search for evidence to incriminate Lane, but must simultaneously tend to her sister, Jessie, who is rushed into the ER. Meanwhile, York returns to the hospital with his mother, who is in need of a risky procedure, and comes face-to-face with the stone-cold Dr. AJ Austin.

A former patient of Link's, named Simon, is in the emergency room with his pregnant wife. Bailey receives an offer from Nick.

A dinner party is thrown at the sister house in Nick's honor; Grey Sloan Memorial receives a victim of a brutal hate crime.

The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.

Susan's mom pays an unannounced visit to Wisteria Lane after she and her boyfriend call it quits. Meanwhile, Gabrielle faces Carlos' wrath after he learns about the hospital settlement and tries to change their prenuptial agreement in order to keep Gabrielle in check while he serves his jail sentence. Lynette and Bree experience a chill in their friendship after Bree babysits Lynette's kids and dares to discipline Porter. Also, Bree and Rex visit Andrew at the teen rehab camp where they learn some shocking news about their son. Lastly, Felicia gets closer to Zach and reveals some disturbing details about his family in the past.

Jo returns for her first full day back from leave; Owen struggles to keep it together when someone close to him is admitted to Grey Sloan; Bailey navigates hospital leadership.

In a final and drastic attempt to save Nic from Lane’s acts of sabotage, Conrad must call in a favor from the one person he promised he never would.

Due to a blood shortage, Grey Sloan Memorial sets up a voluntary donation center. Nick asks Meredith for help with his patient. Winston is hung up on his relationship with his brother.

The blood shortage continues. Meredith makes a risky decision regarding a patient. Owen's actions to help his fellow veterans come to light.

Lynette learns that no good deed goes unpunished when she momentarily befriends the mean Mrs. McClusky. Susan's mother decides to try and jump start her and her daughter's love lives. Andrew talks to a priest about his feelings, and tells him of his shocking plans for his mother, Bree. Gabrielle has her credit card declined in an upscale restaurant, and Carlos sends Gabrielle a big message about what will happen if she leaves him.

Gabrielle plans a big party to bid farewell to Carlos, who is about to head off to jail for eight months. Meanwhile George Williams resurfaces in Bree's life, much to Rex's displeasure. Also, Lynette is shocked to learn that Tom's old girlfriend Annabel Foster who he dumped for Lynette has been hired at his firm again. Meanwhile, Zach continues to stalk Julie while Mike tries to separate Susan from Mary Alice's past secrets. Lastly, housewife Gabrielle is suspecting that she's pregnant.

Andy and Sullivan's relationship continues to be tested. Meanwhile, Emmett joins Dean and Vic on a mental health call, and Maya does some soul searching.

When a magazine editor is discovered dead in her Chestnut Hill mansion, Megan must once again slip back into the high society group she used to be a part of. In order to confront a prime suspect, Megan attends one of her mother's social events.

The mysterious death of a beautiful woman keeps Ethan and Curtis guessing. Curtis begins to question Ethan's motives after he becomes fixated on the dead woman's twin sister.

Jo returns for her first full day back from leave; Owen struggles to keep it together when someone close to him is admitted to Grey Sloan; Bailey navigates hospital leadership.

A criminal lures Rosewood to the murder scene of a former tech millionaire and, in doing so, forces Rosie to re-examine a case from his past.

When a magazine editor is discovered dead in her Chestnut Hill mansion, Megan must once again slip back into the high society group she used to be a part of. In order to confront a prime suspect, Megan attends one of her mother's social events.

Jo returns for her first full day back from leave; Owen struggles to keep it together when someone close to him is admitted to Grey Sloan; Bailey navigates hospital leadership.

Andy and Sullivan's relationship continues to be tested. Meanwhile, Emmett joins Dean and Vic on a mental health call, and Maya does some soul searching.

Lynette learns that no good deed goes unpunished when she momentarily befriends the mean Mrs. McClusky. Susan's mother decides to try and jump start her and her daughter's love lives. Andrew talks to a priest about his feelings, and tells him of his shocking plans for his mother, Bree. Gabrielle has her credit card declined in an upscale restaurant, and Carlos sends Gabrielle a big message about what will happen if she leaves him.

Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.

After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research; accidents at a climate change protest bring unique cases to the hospital; Bailey encounters a blast from the past.

Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support; Richard, Winston and Lucas spend the day outside of the hospital; Blue deals with a relationship from his past; Levi meets the new hospital chaplain.

A blackout at Chastain Memorial Hospital requires the staff to treat their patients without the help of any technology. Bell orders the staff to stop accepting new patients and transfer those on life support, but when a child in need is rushed to the ER, Conrad and Devon go against the mandate. Meanwhile, Mina and Austin are tasked with performing heart surgery on a premature baby, despite the lack of power, and Nic works tirelessly to organize the staff and patients who stay during the blackout.