In a final and drastic attempt to save Nic from Lane’s acts of sabotage, Conrad must call in a favor from the one person he promised he never would.

Emily agrees to help Bill test her for the virus, but soon experiences serious side effects. Sacha, who has secretly followed the group to stay close to Emily, tries to remove her from the group. For their part, Catherine, Sophia and Nathan set out again in search of Bill Ward.

Catherine, Sophia, Zoe and the other survivors, finally reunited, prepare for the ultimate attack. But it is Bill who is the only one to hold the destiny of humanity in his hands, provided he is helped by Isla.

Korvo, increasingly frustrated by Terry, vomits a "red Goobler" – a stress-induced creature intent on killing Korvo. They buy a Jet Ski from Trent, who is killed by the Goobler. Hunting the creature inside a Halloween store, they shrink and capture it. At school, Jesse discovers a flower growing on her head, which releases pollen similar to MDMA, making the popular girls enamored with her. Yumyulack accompanies Jesse to a party and discovers his own flower, with pollen similar to cocaine, and bonds with the popular boys. The mix of Yumyulack and Jesse's pollen creates an effect similar to PCP or bath salts, turning the party-goers bloodthirsty and deranged. Jesse and Yumyulack inform Terry and Korvo, who explain the flowers are a temporary fungus.

After getting kicked out of the A-List villains' Soho Lair, M.O.D.O.K. decides to slum it at The Bar With No Name. There, he forms a crew of street-level baddies, intent on using them for a heist that will get him back into the Soho Lair. However, after a wild night of bonding and backstory sharing, they form a real camaraderie. Meanwhile, Jodie goes looking for M.O.D.O.K. at AIM and bonds with Monica while Lou meets Monica's daughter, Carmilla. College-aged M.O.D.O.K. has returned from the time stream and kidnaps the Super Adaptoid.

Heyo! Terry's obsession with dinner parties gets the whole team in a mess-o-trouble.

The alien’s connection to certain survivors raises difficult questions. Bill makes a startling discovery. Sacha’s behaviour is increasingly erratic. And Tom’s birthday proves cause for celebration. But at what cost?

Tragedy strikes, altering the course of the future forever. Catherine’s priorities change with the arrival of Sophia. Things come to a head between Jonathan and Sacha. And Emily’s so happy she can see again that she’s stopped asking why, even if others haven’t...

The epic series finale sees the survivors attempt to turn the tables on their aggressors once and for all. Mokrani and Catherine prepare for the fight of their lives. Emily seeks answers, at any cost. And Sacha’s visions continue, giving a confounding glimpse of the future…

In a final and drastic attempt to save Nic from Lane’s acts of sabotage, Conrad must call in a favor from the one person he promised he never would.

A blackout at Chastain Memorial Hospital requires the staff to treat their patients without the help of any technology. Bell orders the staff to stop accepting new patients and transfer those on life support, but when a child in need is rushed to the ER, Conrad and Devon go against the mandate. Meanwhile, Mina and Austin are tasked with performing heart surgery on a premature baby, despite the lack of power, and Nic works tirelessly to organize the staff and patients who stay during the blackout.

Catherine faces audits for several of her foundation hospitals. Addison returns to Grey Sloan. Tensions rise between Meredith and Richard; Owen goes back to work.

A former patient of Link's, named Simon, is in the emergency room with his pregnant wife. Bailey receives an offer from Nick.

A dinner party is thrown at the sister house in Nick's honor; Grey Sloan Memorial receives a victim of a brutal hate crime.

Due to a blood shortage, Grey Sloan Memorial sets up a voluntary donation center. Nick asks Meredith for help with his patient. Winston is hung up on his relationship with his brother.

Relationships are challenged at Station 19 following Sullivan's actions at Maya and Carina's wedding, putting his marriage with Andy to the test. Dean comes to terms with his feelings for Vic, while Travis rekindles an old flame. The annual Phoenix Festival brings out some reckless behavior in some of Seattle's citizens, challenging the teams at Station 19 and Grey Sloan Memorial.

Andy and Sullivan's relationship continues to be tested. Meanwhile, Emmett joins Dean and Vic on a mental health call, and Maya does some soul searching.

When a heat wave hits Seattle, Station 19 becomes a cooling center. Andy deals with regret and finds a friend in Theo. Joey comes face-to-face with his past during a ride-along with Ben and Jack.

Maisy Gibbons' series of unfortunate events shock the residents of Wisteria Lane when she is finally caught and arrested for prostitution. This leaves unexpected consequences for Bree and Rex when Maisys' little black book becomes public of all her clients. Gabrielle and Carlos also face a crisis of their own when the sewer system goes out at their house. Also, Lynette braves a scandal herself when it's rumored that the twins started the school's head lice epidemic. Meanwhile, as Susan sinks into depression over her breakup with Mike, she finds a surprising ally.

The residents of Wisteria Lane all attend the unfortunate funeral of Juanita Solis as Carlos and Gabrielle fret over their financial and court issues. Lynette befriends a deaf woman, Alisa Stevens, whose children also attend Barcliff Academy with Porter and Preston, but her newfound friendship is quickly put to the test. Meanwhile, Bree encounters more trouble with her son Andrew when it comes to disciplining him and lastly, Susan finds herself attracted to Edie's hunky new contractor, but Edie doesn't want her to go with him as a favor to their fragile friendship.

Megan unravels the details surrounding a stay-at-home dad's stabbing death in his suburban home. Megan enlists Peter's help when she takes on a Saturday carpool for Lacey and her girlfriends.

When Vic helps her parents through a devastating loss, they have a long overdue conversation about the anguish of being Black in America.

Maya addresses some unresolved family issues, and the crew takes matters into their own hands when faced with a life-or-death moment on scene. Meanwhile, Andy and Sullivan's marriage is put to the test.

The mysterious death of a beautiful woman keeps Ethan and Curtis guessing. Curtis begins to question Ethan's motives after he becomes fixated on the dead woman's twin sister.

When a magazine editor is discovered dead in her Chestnut Hill mansion, Megan must once again slip back into the high society group she used to be a part of. In order to confront a prime suspect, Megan attends one of her mother's social events.

Megan unravels the details surrounding a stay-at-home dad's stabbing death in his suburban home. Megan enlists Peter's help when she takes on a Saturday carpool for Lacey and her girlfriends.

Soto reopens an old murder case, determined to uncover the true killer in classic "whodunit" style.

A criminal lures Rosewood to the murder scene of a former tech millionaire and, in doing so, forces Rosie to re-examine a case from his past.

Jo returns for her first full day back from leave; Owen struggles to keep it together when someone close to him is admitted to Grey Sloan; Bailey navigates hospital leadership.

The blood shortage continues. Meredith makes a risky decision regarding a patient. Owen's actions to help his fellow veterans come to light.

After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research; accidents at a climate change protest bring unique cases to the hospital; Bailey encounters a blast from the past.

The new neighbors, the Applewhites have moved in. Gabrielle, Lynette, and Susan attempt to comfort Bree while Rex's mother arrives on Wisteria Lane for his funeral. Meanwhile Mike and Susan deal with Zach while Gabrielle struggles with the two men in her life.

Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant; Teddy offers Amelia a new opportunity; Ben's interview doesn't go as planned; Meredith's secret causes tension with Richard.

Mika struggles with a life-altering personal matter; Bailey and Ben navigate their personal and professional roles; Levi finds a connection in an unlikely place; Jo and Link get surprising news.

Bell grows frustrated when Marshall Winthrop, Conrad’s dad and new chairman of the board, requests Conrad’s input in his discussions about the hospital’s expenses. As Conrad and Nic work to cut costs for their patients in need, Julian Lynn, a sharp and sophisticated medical device rep, meets the staff at Chastain and inserts herself into the ongoing work of the doctors to promote her costly products. Meanwhile, Mina’s relationship with Micah struggles in the wake of his healing process, and Devon is tasked with showing the eager new interns around the hospital.