Diane returns to help with Crisis One intervention training for Station 19 and Station 23 firefighters. Andy and Sullivan continue to be at odds. Jack helps a young autistic man on a city bus.

As people across the globe are experiencing hallucinations, MI5 agent Zoe contacts Bill for answers; Catherine Durand detects unusual black hole activity.

As Adina starts the next stage of her plan, astronauts Juliet and Richard see warning signs in space; uncovering Adina's sinister mission.

Trying to emulate human males, Korvo and Terry create their own man cave and “"P.A.T.R.I.C.I.A.", a robot based on female sitcom characters, programmed to hate the man cave. Korvo and Terry realize the robot fulfills their respective desires for a nagging wife and a nurturing mother, and invite her inside the man cave. Torn between her conflicting directives, P.A.T.R.I.C.I.A. transforms into a heavily-armed killing machine and destroys every man cave in the neighborhood. Ms. Perez, Jesse's gender studies teacher, assigns the class to challenge a glass ceiling. Jesse confronts several school extracurriculars, but is disappointed to learn they already welcome women.

M.O.D.O.K., finding himself stifled by GRUMBL’s bureaucratic control of AIM, teams up with Monica to take down their new bosses. Monica's hatred toward M.O.D.O.K. remains, however, and she ends up betraying M.O.D.O.K., causing the two to have a mad scientist duel, which M.O.D.O.K. loses in front of his whole company. Monica is promoted to Scientist Supreme and M.O.D.O.K. is stripped of his authority. Meanwhile, Jodie's life without M.O.D.O.K. flourishes as one of her videos goes viral, launching her into internet fame.

Far out! Korvo and Terry manipulate each other with time travel while Yumyulack grows a fat hog.

London, four months after the attack. The survivors organize the Resistance. Bill continues his research on aliens and understands that their DNA is human but that their organs are degenerating. In France, a severely wounded dissident alien reaches the Observatory

After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research; accidents at a climate change protest bring unique cases to the hospital; Bailey encounters a blast from the past.

Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support; Richard, Winston and Lucas spend the day outside of the hospital; Blue deals with a relationship from his past; Levi meets the new hospital chaplain.

Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.

Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.

A blackout at Chastain Memorial Hospital requires the staff to treat their patients without the help of any technology. Bell orders the staff to stop accepting new patients and transfer those on life support, but when a child in need is rushed to the ER, Conrad and Devon go against the mandate. Meanwhile, Mina and Austin are tasked with performing heart surgery on a premature baby, despite the lack of power, and Nic works tirelessly to organize the staff and patients who stay during the blackout.

After firing some of Grey Sloan's best, Catherine continues to interfere with Meredith and Amelia's research; accidents at a climate change protest bring unique cases to the hospital; Bailey encounters a blast from the past.

Meredith and Catherine continue to disagree, and Meredith confides in Bailey for support; Richard, Winston and Lucas spend the day outside of the hospital; Blue deals with a relationship from his past; Levi meets the new hospital chaplain.

Bree begins to feel guilty about her friendship with George while Rex's health continues to depreciate. Lynette tries to spice things up with Tom who, she fears, is losing interest. Meanwhile, Mr. Shaw consults with Paul, and ends up lying to Susan. After talking with Kendra Susan learns what Mike did. Gabrielle tells John that she is pregnant, and John doesn't take the news well. Lastly, Felicia takes action to help Zach, and to get rid of Paul for good.

Susan and Mike decide to move in together, much to Edie's displeasure. Meanwhile, Lynette takes steps to make sure Annabel doesn't come between her and Tom. Also, Bree comes to a realization about her "buddy" George the pharmacist who continues to interfere in her and Rex's lives. Carlos' legal problems take a turn for the worse, when Gabrielle decides to leave him. Mrs. Huber's journal reveals some secrets. Lastly, two new faces arrive on Wisteria Lane.

When Melinda goes to visit friends who are experiencing problems with their house, she finds the ghost of six-year-old little girl who drowned. Melinda then tries to help the family of the little girl.

Bell grows frustrated when Marshall Winthrop, Conrad’s dad and new chairman of the board, requests Conrad’s input in his discussions about the hospital’s expenses. As Conrad and Nic work to cut costs for their patients in need, Julian Lynn, a sharp and sophisticated medical device rep, meets the staff at Chastain and inserts herself into the ongoing work of the doctors to promote her costly products. Meanwhile, Mina’s relationship with Micah struggles in the wake of his healing process, and Devon is tasked with showing the eager new interns around the hospital.

Simone and Lucas work to balance their relationship while competing to assist on an awake kidney transplant; Teddy offers Amelia a new opportunity; Ben's interview doesn't go as planned; Meredith's secret causes tension with Richard.

Mika struggles with a life-altering personal matter; Bailey and Ben navigate their personal and professional roles; Levi finds a connection in an unlikely place; Jo and Link get surprising news.

Bree confides that she feels guilty because she and Rex were having a fight when he had his heart attack and that now he needs a pacemaker. Lynette's marriage takes a dramatic turn after an upset Tom vows that it is now her turn to go back to work and he'll be staying home with the kids. Carlos finally learns that John and Gabrielle have been lovers for a while, and vows revenge as he is carted off to jail. Mike takes Paul out to a deserted quarry, intending to shoot him.

The new neighbors, the Applewhites have moved in. Gabrielle, Lynette, and Susan attempt to comfort Bree while Rex's mother arrives on Wisteria Lane for his funeral. Meanwhile Mike and Susan deal with Zach while Gabrielle struggles with the two men in her life.

Diane returns to help with Crisis One intervention training for Station 19 and Station 23 firefighters. Andy and Sullivan continue to be at odds. Jack helps a young autistic man on a city bus.

When a Philadelphia homicide detective is the victim of a hit-and-run, Megan must seek help with the case from her estranged mother, Judge Joan Hunt. All the while, Megan realizes she misses her own close relationship with her daughter.

Megan unravels the details surrounding a stay-at-home dad's stabbing death in his suburban home. Megan enlists Peter's help when she takes on a Saturday carpool for Lacey and her girlfriends.

When Melinda goes to visit friends who are experiencing problems with their house, she finds the ghost of six-year-old little girl who drowned. Melinda then tries to help the family of the little girl.

The FBI joins the investigation into the murder of a controversial tech magnate, forcing Karadec to reunite with his former partner; Ludo becomes overwhelmed with his increasing childcare duties.

When a Philadelphia homicide detective is the victim of a hit-and-run, Megan must seek help with the case from her estranged mother, Judge Joan Hunt. All the while, Megan realizes she misses her own close relationship with her daughter.

When Melinda goes to visit friends who are experiencing problems with their house, she finds the ghost of six-year-old little girl who drowned. Melinda then tries to help the family of the little girl.

Diane returns to help with Crisis One intervention training for Station 19 and Station 23 firefighters. Andy and Sullivan continue to be at odds. Jack helps a young autistic man on a city bus.

Bree confides that she feels guilty because she and Rex were having a fight when he had his heart attack and that now he needs a pacemaker. Lynette's marriage takes a dramatic turn after an upset Tom vows that it is now her turn to go back to work and he'll be staying home with the kids. Carlos finally learns that John and Gabrielle have been lovers for a while, and vows revenge as he is carted off to jail. Mike takes Paul out to a deserted quarry, intending to shoot him.

Susan tries bravely to accept Edie’s new role in Julie’s life, while Lynette’s demanding boss makes her miss Parker’s first day of kindergarten. Bree later on takes a polygraph test to prove her innocence in Rex's death and realizes she has feelings for George. Gabrielle finally comes to the truth about Carlos and John after seeing John with another woman.

The fates of a patient in critical condition and a helicopter-bound medical team hang in the balance; Teddy and Owen work on their marriage; Bailey, Blue and Link treat a hospital employee.

Teddy and Owen plan a date night that gets derailed in more ways than one; Jo struggles to do it all at home; Mika adds more to her plate to make up for taking time off to be with her sister; Levi is faced with a monumental decision.

Nic and Conrad contemplate their past when they team up to diagnose a happy husband and wife who are both admitted to the hospital with mysterious symptoms. Bell and Marshall butt heads on a work trip when their cut-throat business tactics don’t align. Meanwhile, AJ turns down a request from Bell despite Mina’s forewarning, Devon continues to gravitate to medical device rep Julian and the staff gears up for Conrad’s three-year anniversary at Chastain.