It's the most wonderful time of the year and the firefighters have their hands full responding to a number of crises throughout Seattle. Putting aside their differences and personal drama, they come together to try and achieve a Christmas miracle.

When astrophysicists detect a transmission from another galaxy, it is definitive proof of intelligent extra-terrestrial life. The world's population waits for further contact with baited breath. They do not have to wait long. Within days, mankind is all but wiped out; just pockets of humanity are left in an eerily deserted world.

After the devastating alien attack, disparate pockets of survivors emerge into a shattered world. They quickly realise they must put their differences aside if they are to stand any chance of survival.

Blimey! The Solar Opposites have repaired their ship and are heading to space, unless something goes hilariously wrong...

M.O.D.O.K. suddenly starts acting like a model employee, dutifully delivering mail and making tablets. Austin has a change of heart and tries to inform M.O.D.O.K. who really is running GRUMBL. Thrown by M.O.D.O.K.’s new behavior, Gary thinks it's Austin's fault, and Monica suspects M.O.D.O.K. is planning something against her. Eventually, M.O.D.O.K. reveals that he is selling his shares in AIM to Tony Stark and starts a new business with Monica. Austin misses the chance to tell M.O.D.O.K. the truth about GRUMBL.

Oops! The wild story that explains why Terry had to order a new shot glass.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

The aftermath of the convenience store shooting brings chaos to Grey Sloan; Ben hits a wall with his new emergency preparedness plan; romantic tensions surface for Owen; Amelia and Winston disagree over the surgical plan for a young patient.

Meredith and Nick return to Grey Sloan to treat a liver transplant patient; Bailey hosts an intern retreat at her home; Winston and Ben aid an unexpected crash victim.

Mike and Susan face a crisis in their relationship when Susan tries to get Paul Young arrested by confessing to a police officer that he killed Mrs. Huber and Mike has her diaries as proof. The officer goes over to Mike to get the story, but Mike denies the whole thing. As Carlos continues serving his jail sentence, Gabrielle valiantly tries to free him. Bree goes to a romantic hotel with George, but requests they sleep in separate rooms.

Gabrielle tries to revisit her past when old friends come to town, but doesn't want anyone to know that she's three months pregnant. With the aftermath of her breakup with Mike, Susan finds temporary solace from her ex-husband Karl as his relationship with Edie hits a bump. Also, the Scavos learn more about the new neighbors, the Harpers when they babysit their children and uncover a sex tape of the couple. Lastly, Caleb gets loose from the basement and roams around Wisteria Lane at night, which leads to major consequences for Gabrielle.

When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.

The aftermath of the convenience store shooting brings chaos to Grey Sloan; Ben hits a wall with his new emergency preparedness plan; romantic tensions surface for Owen; Amelia and Winston disagree over the surgical plan for a young patient.

Meredith and Nick return to Grey Sloan to treat a liver transplant patient; Bailey hosts an intern retreat at her home; Winston and Ben aid an unexpected crash victim.

Mike and Susan face a crisis in their relationship when Susan tries to get Paul Young arrested by confessing to a police officer that he killed Mrs. Huber and Mike has her diaries as proof. The officer goes over to Mike to get the story, but Mike denies the whole thing. As Carlos continues serving his jail sentence, Gabrielle valiantly tries to free him. Bree goes to a romantic hotel with George, but requests they sleep in separate rooms.

Gabrielle tries to revisit her past when old friends come to town, but doesn't want anyone to know that she's three months pregnant. With the aftermath of her breakup with Mike, Susan finds temporary solace from her ex-husband Karl as his relationship with Edie hits a bump. Also, the Scavos learn more about the new neighbors, the Harpers when they babysit their children and uncover a sex tape of the couple. Lastly, Caleb gets loose from the basement and roams around Wisteria Lane at night, which leads to major consequences for Gabrielle.

The hunt for a counterfeit currency kingpin allows the team to get a glimpse into Villa’s past. Meanwhile, Rosie receives surprising news about his recent health issue.

Halloween at Chastain proves to be just as spooky as ever when Conrad is tasked with diagnosing a young woman admitted to the hospital with extreme night terrors. Meanwhile, Devon faces his first Halloween in the ER, Nic panics over her decision to bring her newly sober sister to Mina's epic annual Halloween party and Bell finds an interesting way to make use of his new assistant.

Following a difficult case, the team faces the complexities of medical ethics; Bailey continues to navigate her working relationship with Ben; a group of college students on a scavenger hunt causes chaos around the hospital.

Meredith and Amelia prepare a funding proposal for their Alzheimer's research; Teddy and Owen hit a breaking point in their marriage; Jules has an awkward encounter with Dr. Beltran.

All of Wisteria Lane is panicked by a burglar loose in the neighborhood and thus a neighborhood watch committee is formed. Bree finds out some disturbing information about George. At the wedding of Sophie and Morty, Susan learns who her real father is and is determined to find him.

George stalks Bree, despite her efforts to break up with him. Lynette takes charge of office politics. Carlos is paroled from prison and returns a new man, and Gabrielle is jealous of his new 'holier-than-thou' confidante. Susan meets her birth father and tries to begin a relationship with him.

It's the most wonderful time of the year and the firefighters have their hands full responding to a number of crises throughout Seattle. Putting aside their differences and personal drama, they come together to try and achieve a Christmas miracle.

Megan investigates the death of a young nanny run down by a car and discovers that her 5-year-old charge has been kidnapped -- and requires medication. A handsome FBI agent, Derek Ames, is assigned to the case.

When a wealthy tycoon's much younger new wife, Julie Loeb, is shot at a family deer-hunting outing, suspects abound. The tycoon, Martin Loeb, is such a likely suspect that Megan openly accuses him and is fired from the case by Kate, at the request of the highly-influential Martin.

The hunt for a counterfeit currency kingpin allows the team to get a glimpse into Villa’s past. Meanwhile, Rosie receives surprising news about his recent health issue.

After purchasing a set of ornaments at a flea market, Melinda finds that they are haunted. Melinda uses the ornaments to meet Dennis’s ghost. Dennis wants Melinda to reunite his girlfriend with her birth mother.

Megan investigates the death of a young nanny run down by a car and discovers that her 5-year-old charge has been kidnapped -- and requires medication. A handsome FBI agent, Derek Ames, is assigned to the case.

The hunt for a counterfeit currency kingpin allows the team to get a glimpse into Villa’s past. Meanwhile, Rosie receives surprising news about his recent health issue.

It's the most wonderful time of the year and the firefighters have their hands full responding to a number of crises throughout Seattle. Putting aside their differences and personal drama, they come together to try and achieve a Christmas miracle.

All of Wisteria Lane is panicked by a burglar loose in the neighborhood and thus a neighborhood watch committee is formed. Bree finds out some disturbing information about George. At the wedding of Sophie and Morty, Susan learns who her real father is and is determined to find him.

All of Wisteria Lane is panicked by a burglar loose in the neighborhood and thus a neighborhood watch committee is formed. Bree finds out some disturbing information about George. At the wedding of Sophie and Morty, Susan learns who her real father is and is determined to find him.

Station 19 and Station 23 each attempt to celebrate Thanksgiving following the fallout from the neighborhood explosion. The firefighters come together to cook, toast to loved ones they have lost, and celebrate the families they have become.

Vic and Jack lean on one another as they process the loss of Dean while Ben and Bailey try to convince Dean's parents to allow them to raise Pru. Meanwhile at Station 23, Andy's role temporarily expands and Sullivan subs in. Carina and Maya explore growing their family.

It's the most wonderful time of the year and the firefighters have their hands full responding to a number of crises throughout Seattle. Putting aside their differences and personal drama, they come together to try and achieve a Christmas miracle.

All of Wisteria Lane is panicked by a burglar loose in the neighborhood and thus a neighborhood watch committee is formed. Bree finds out some disturbing information about George. At the wedding of Sophie and Morty, Susan learns who her real father is and is determined to find him.