The Dean Miller Memorial Clinic has its opening day. Meanwhile, Sullivan gives Beckett an ultimatum, and the crew responds to a skydiving incident.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

At the university, Sophia watches the videos recorded by Dylan, a young man they found dead, while Catherine focuses on the algorithms he left behind and which decipher the behavior of robots. Thanks to Bill's intervention, Isla manages to flee and join her family.

Super villain M.O.D.O.K. runs his evil organization AIM into the ground and is forced to sell it to the tech company GRUMBL. As the megalomaniacal M.O.D.O.K. struggles to regain control of AIM, he risks losing something even more important…his family!

Super villain M.O.D.O.K. runs his evil organization AIM into the ground and is forced to sell it to the tech company GRUMBL. As the megalomaniacal M.O.D.O.K. struggles to regain control of AIM, he risks losing something even more important…his family!

In a bid to save his marriage, M.O.D.O.K. takes Jodie back in time to a concert they missed when they were in college. During a detour to kill the child-version of his GRUMBL boss, M.O.D.O.K. and Jodie are attacked by college-aged M.O.D.O.K., who accidentally absorbs their time crystals, stranding them in 2002. The couple reconciles but is stuck in the past until they catch up to the present. Once in the present, they prevent themselves from ever going to the past in the first place, erasing their entire adventure from the timeline.

With Adina's plan for world destruction reaching completion, and our heroes in the alternate world under attack, both sides must make great sacrifices if they are to save humanity.

Jo and Link's wedding day arrives, along with some visitors; Teddy and Owen are met with a familiar face seeking treatment; Lucas disagrees with Simone on how to approach a patient's worsened condition.

The interns are excited to transition to second-year residency; a medical emergency unfolds in the operating room, endangering lives inside the hospital.

Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian (guest star Jenna Dewan) makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.

Jo and Link's wedding day arrives, along with some visitors; Teddy and Owen are met with a familiar face seeking treatment; Lucas disagrees with Simone on how to approach a patient's worsened condition.

The interns are excited to transition to second-year residency; a medical emergency unfolds in the operating room, endangering lives inside the hospital.

Tom tries hard to bond with his new boss and tries to get Lynette to help him out. Meanwhile, Susan gets some help from Edie and Karl on her situation of getting health insurance before her upcoming surgery. Gabrielle becomes very attached to a temporary Chinese immigrant housekeeper who is staying with Solis' after being rescued by another slave owner employer. Lastly, Bree tries to uncover more about the Applewhites by sneaking into their house to meet Caleb.

Edie thinks that Karl is going to pop the question after she finds an engagement ring and prenuptial agreement in his briefcase. Also, Gabrielle and Carlos learn she is highly unable to conceive a child again because of complications caused from her recent miscarriage. Lastly, Bree's problem with alcohol intensifies with the notice of Lynette after Bree babysits her children.

After a catastrophic bridge collapse sends dozens of victims to Grey Sloan, the hospital activates its full disaster response as they race to treat a surge of critically injured patients.

Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.

After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own; confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations; Meredith spends time with Amelia.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Susan invites Dr. Ron to meet Karl after he finds out about their arranged marriage. Lynette is surprised that a woman at work is still breastfeeding her child of five. Gabrielle becomes very picky when choosing a birth mother, and a beautiful baby. Bree has to deal with a fresh accusation from Andrew, that of repressed memories.

The Dean Miller Memorial Clinic has its opening day. Meanwhile, Sullivan gives Beckett an ultimatum, and the crew responds to a skydiving incident.

When a popular 17-year-old high school student is found dead after a rave, the team must decipher various unknown drugs in his system and multiple bruises to figure out the cause of death.

A champion equestrian is killed and potential drug use is suspected, but when Megan's daughter, who also rides, overhears details of the case, she leads the team to a clue and possibly the murderer.

After a catastrophic bridge collapse sends dozens of victims to Grey Sloan, the hospital activates its full disaster response as they race to treat a surge of critically injured patients.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America’s space program. Rosie navigates new dynamics regarding his latest health issue, and Villa’s long-lost brother returns to Miami.

When a popular 17-year-old high school student is found dead after a rave, the team must decipher various unknown drugs in his system and multiple bruises to figure out the cause of death.

After a catastrophic bridge collapse sends dozens of victims to Grey Sloan, the hospital activates its full disaster response as they race to treat a surge of critically injured patients.

The Dean Miller Memorial Clinic has its opening day. Meanwhile, Sullivan gives Beckett an ultimatum, and the crew responds to a skydiving incident.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

A high-risk lung transplant pushes the surgical team to their limits; Bailey juggles a trauma patient whose treatment hangs in the balance.

The interns juggle a bizarre trauma; a complex breast reconstruction forces Meredith into a tense partnership.

When a medical device fails on a former Chastain employee, an investigation is opened up, which pits Dr. AJ Austin against Quovadis. As Mina and Bell work to get to the bottom of what went wrong, Devon distracts himself with another patient who's experiencing mysterious stomach pains. Meanwhile, Nic forms a bond with her new partner at the clinic and Conrad's relationship with the Barnett family continues to grow.