When remains of real estate agent Justin Ross are found in the forest and appear to have been destroyed by coyote-wolf hybrids, Brennan enlists the help of fellow brilliant forensic anthropologist Dr. Beth Mayer (guest star Betty White) to assist in the investigation. In addition to her professional achievements, Mayer is surprisingly knowledgeable about the world of fantasy football, a key link to Ross' past and one that could provide vital information in finding his killer. As Booth and Aubrey dig into Ross' fantasy football league history, they discover he was actively involved in a Twitter feud with NFL star Lou Divers (guest star Ronde Barber), and was also owed a large sum of money from the league's commissioner, making each of them suspects. Meanwhile, Brennan resists feeling competitive as Mayer impresses the team with her expertise and decades of accomplishments.

Catherine, Sophia and Nathan make their way to London, accompanied by Victor, a survivor encountered by chance. Along the way, the dangers multiply. Sacha's feelings towards Emily intensify and the young man's behavior becomes more and more disturbing. Feeling threatened, Bill is forced to flee.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

Dinner Time! Korvo wins top prize at the annual neighborhood rib festival.

Young M.O.D.O.K. has kidnapped the family and replaced them with robots that trick M.O.D.O.K. into thinking Jodie wants him back. M.O.D.O.K. learns the truth and goes to free his real family. The family meet up inside the carnival-themed arena Murderworld, where young M.O.D.O.K. and Arcade reveal that each family member has two robotic replicas and that they must fight to the death, unsure of who is real or fake. Jodie goes toe-to-toe with Young M.O.D.O.K. The family leaves feeling united for the first time in a while.

With Adina's plan for world destruction reaching completion, and our heroes in the alternate world under attack, both sides must make great sacrifices if they are to save humanity.

With Adina's plan in motion, the world's last hope is for Bill to make one more journey, risking his own life in search of Catherine's help.

The 126 are called on the scene to a hoarder’s rat-infested house, then are trapped in an elevator as a woman goes into labor; Tommy and Trevor host his ex-wife Cassandra for dinner which goes awry.

The 126 race into action when a horse barrels into a brewery with an unconscious rider on its back and then to a bus full of tourists all experiencing seizures. Judd introduces Owen to Wyatt’s mother Marlene. Carlos and T.K. start couples counseling, when Carlos investigation into his father’s murder becomes all-consuming.

The 126 race to save a man crushed under a vending machine. While struggling to handle his aggressive foster horse, Owen finally faces the truth of his brother’s death. As Mateo and Nancy scramble to delete a nude photo of her accidentally sent to the 126, Tommy is concerned that Nancy may be facing a possible health scare.

A robbery-homicide prompts Beckett to invite Det.Demming to assist on the case; the investigation becomes a competition for Beckett's attention, since both men race to solve the case.

Castle and Beckett investigate what appears to be the assassination of an intelligence operative. Meanwhile, Beckett continues her romance with Demming, jeopardizing her relationship with Castle. Forcing them to finally face down their feelings for each other.

When Beckett and her team burst into a shadowy apartment on the trail of a murderer, the last thing they expect to see is Castle standing over a dead woman's body holding a gun! As Castle protests his innocence, Beckett has to arrest him

The BAU is called to Salt Lake City, Utah to investigate a suspicious triple-homicide. They eventually discover that a fugitive killer could possibly be linked to the UnSub and he could also be a familiar face.

The BAU searches Tallahassee for a serial killer who calls the authorities to report the crimes prior to committing them. Also, as Rossi prepares for a weekend visit with his daughter, Joy, he receives startling news about the death of a comrade from the Vietnam War.

The BAU heads to Indianapolis, Indiana where a bomb has just exploded at a popular chain coffee house, killing several. The police believe this bomb is related to a bombing one week earlier at a school.

Mysteries abound when pallbearers at a funeral lose control of a surprisingly heavy casket only to have a second unknown woman tumble out along with the original deceased.

Responding to an "Officer Down" emergency call, Castle and Beckett's latest case takes a shocking turn when it's revealed that the victim isn't a cop but a male stripper dressed up as one.

When the Jeffersonian team discovers remains of a victim, and elements of the crime scene point to a possible protégé of serial killer Christopher Pelant, they must revisit their prior work on Pelant while tracing new clues that will hopefully lead them to the copycat killer. Meanwhile, Angela is skeptical about her and Hodgins decision to move to Paris and Brennan and Booth contemplate options outside of the Jeffersonian and FBI.

Six months after the events of last season, Booth, Brennan, daughter Christine and the new baby are ostensibly living a dream life, a world away from the murder-filled life they left behind. But a case with close personal ties to the couple compels Brennan to become involved in the forensic analysis of the remains, and Booth mysteriously goes missing, prompting an FBI investigation into his whereabouts led by Agent Grace Miller, who works closely with FBI Agent James Aubrey on the case.

When frozen bodies are found in Nevada floating in water, the BAU’s investigation leads them to suspect that the victims were part of a cult that could be behind the deaths. Also, JJ confronts old demons from her abduction and torture last year.

The members of the BAU team are brought back to their origins as they look at one of Gideon and Rossi's old cases.

Peter Folkmore was an abused child and is an abuser as an adult. He captures women and abuses them for not reciting the exact instruction Peter gives them.

While Harrow investigates a baffling crime involving siblings, James brings danger closer to his half-sister Fern than ever before - and pays a high price.

Harrow rides the storm when a deathly ill boy at QIFM needs his help at the very moment Mila Zoric summons him to negotiate his kidnapped son's release. But there's one lightning bolt shock he did not see coming.

When the Jeffersonian team discovers remains of a victim, and elements of the crime scene point to a possible protégé of serial killer Christopher Pelant, they must revisit their prior work on Pelant while tracing new clues that will hopefully lead them to the copycat killer. Meanwhile, Angela is skeptical about her and Hodgins decision to move to Paris and Brennan and Booth contemplate options outside of the Jeffersonian and FBI.

Six months after the events of last season, Booth, Brennan, daughter Christine and the new baby are ostensibly living a dream life, a world away from the murder-filled life they left behind. But a case with close personal ties to the couple compels Brennan to become involved in the forensic analysis of the remains, and Booth mysteriously goes missing, prompting an FBI investigation into his whereabouts led by Agent Grace Miller, who works closely with FBI Agent James Aubrey on the case.

When body parts of a Coast Guard Reservist are found in the belly of a poached wild boar, Longworth hunts the killer into the depths of the Glades.

When Colter suddenly disappears during his search for a missing father, Reenie recruits his brother, Russell (Jensen Ackles), for help.

The team investigates a network killer who buries his victims alive.

Dr. Daniel Harrow investigates the apparent suicide of a young woman whose grieving father suspects she was murdered.

While stalling the river bones investigation, Harrow digs into the case of a woman murdered with a crossbow, coming dangerously close to a thrill-kill murderer.

A human arm in a dead crocodile leads Harrow and Dass to Far North Queensland, battling crocs and crooks in their pursuit of the truth.