A Station 19 firefighter lands in the emergency room for severe burn treatment; the team treats an elderly patient impaled by an art structure.

When the team responds to an apartment fire, Captain Pruitt takes a hit, the future of the station’s leadership is in jeopardy and firefighter Andy Herrera is forced to step up. Meanwhile, new recruit Ben Warren is trading in the scalpel for a fresh start as a firefighter, but it hasn’t been easy and he has a hard time realizing that emergencies in the field are vastly different than those at Grey Sloan Memorial.

With the absence of Captain Pruitt, Andy and Jack try to navigate how to work together, and a car accident on a rural road puts both the victims and the crew’s lives at risk.

Tom and Lynette try to make Kayla feel like a part of the family. Alma Hodge decides to pay Orson and Bree a visit. Susan visits Mike in jail to tell him about the lawyer Ian got him. Gabrielle accuses Carlos of trying to sabotage her relationship with Bill. Bree organizes a dinner party to show Susan that Alma is alive.

Bree isn't happy Alma has moved to Wisteria Lane. Gabrielle's secret admirer is revealed. The new Scavo Pizzeria faces an uncertain future. Julie and Austin go to Edie about giving them parental consent to buy birth control pills.

Gabrielle cannot avoid Zach. Mike's new lawyer suggests he pleads guilty, but Susan doesn't agree with that. Gloria informs Bree that she and Alma believe Bree is the other woman. Instead of going back to work Lynette pretends to be ill so she can help Tom promote the pizzeria at a food fair.

A case of mistaken identity mars a case when two young girls are in a tragic car accident. The wrong girl may have been pronounced dead and the actual cause of death is in question.

Melinda and Jim's trip is interrupted as Melinda helps the ghost of a woman who left her husband and young daughter. Before the woman can cross over Melinda must find the woman’s daughter and help her to learn the truth about her parent’s past.

A legendary lawyer comes out of retirement. Liberty weighs a pivotal decision.

Dr. Hunt and the team examine a family restaurant business when the owner turns up dead in the freezer.

A dead body found in the trunk of a car leads the team to another body. Megan meets up with an old friend and Kate feels her job is in jeopardy.

When a son discovers his murdered parents, the team soon realizes that this perfect family wasn't really perfect. Megan has a new love interest and Curtis is grappling with his new position.

Edie gets an unexpected visit from her son. An unexpected pregnancy causes complications. Victor Lang, a man in his 40s running for mayor of Fairview, introduces himself for Gabrielle. The deceased Rex Van De Kamp narrates.

Susan meets her in-laws and finds out some family. Victor is still taking his chances with Gabrielle, while she has a devastating catastrophe at her home. Lynette is encountering new problems at the pizzeria while an unexpected relationship develops on Wisteria Lane.

Susan considers moving from Wisteria Lane to London. Later, an accident causes Ian, Susan, and their car to find themselves stranded in a lake. Tom feels threatened by the interest a new Scavo's Pizzeria employee Rick shows in Lynette. While debating his opponent in the mayoral election, Victor Lang witnesses something disturbing.

Dr. Hunt and the team examine a family restaurant business when the owner turns up dead in the freezer.

A dead body found in the trunk of a car leads the team to another body. Megan meets up with an old friend and Kate feels her job is in jeopardy.

Grey Sloan sees the return of a familiar face; Catherine puts on the pressure, forcing Bailey to make a decision about Alex; Amelia faces a tough case at the ER.

The surgeons work together to save the life of the Raptor's old mentor, Abe, who is their only inside source to Quovadis. Unfortunately, when Nic and Conrad take on a patient needing the hospital's only viable ECMO machine, they must decide between saving the life of Abe or saving the life of their younger, more stable patient. Meanwhile, Marshall puts himself in serious danger to help take down Gordon Page once and for all.

Chastain picks up the pieces after the fall out with the corrupt medical device company Quovadis, leaving Marshall ready to charter new territory in the medical field, and Devon to finally discover the truth about what happened to Julian Booth. As Conrad and Alec team up to help a young gymnast experiencing mysterious symptoms, Nic focuses on her sister, who's back with their estranged father, Kyle, in tow. Meanwhile, Bell rushes to Kit's aid when her ex-husband comes to the ER needing emergency surgery.

When Atlanta is struck by a severe snowstorm, Mina must perform a big surgery – without the help of The Raptor – to save the life of a young father, while Kit and Bell get stuck babysitting the man's children. Nic and Conrad experience a disagreement with a patient's treatment, causing further strain in their relationship. Meanwhile, Devon teaches an important lesson about life and death to a first-year med student.