The doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

At the university, Sophia watches the videos recorded by Dylan, a young man they found dead, while Catherine focuses on the algorithms he left behind and which decipher the behavior of robots. Thanks to Bill's intervention, Isla manages to flee and join her family.

Inside the Wall, Tim – imprisoned and tortured on the Duke's orders – is convinced by his cellmate Jean-Pierre to write letters calling for revolution. They are rescued by Cherie and her fellow rebels, and prepare to overthrow the Duke. Tim and Cherie spend a passionate night together, and copies of Tim's letters spread throughout the Wall, drawing people to their cause; Cherie urges Tim to lead them. As the Duke addresses a congregation, his sheriff spots Tim in the crowd and attacks, killing Jean-Pierre. Tim unites the oppressed inhabitants of the Wall in an open rebellion. The Duke floods the lower levels, drowning countless people; a farmer named Steven is unable to save his beloved mouse, Molly.

M.O.D.O.K., finding himself stifled by GRUMBL’s bureaucratic control of AIM, teams up with Monica to take down their new bosses. Monica's hatred toward M.O.D.O.K. remains, however, and she ends up betraying M.O.D.O.K., causing the two to have a mad scientist duel, which M.O.D.O.K. loses in front of his whole company. Monica is promoted to Scientist Supreme and M.O.D.O.K. is stripped of his authority. Meanwhile, Jodie's life without M.O.D.O.K. flourishes as one of her videos goes viral, launching her into internet fame.

Jodie's celebrity is on the rise and M.O.D.O.K. plans on winning her back from her new boyfriend, the superhero Wonder Man. Jodie and her publicist invite M.O.D.O.K. to a party, knowing his temper will bring publicity. M.O.D.O.K. provokes Wonder Man into attacking him at the party and is kicked out. Wonder Man leaves Jodie when he sees she’s only using him for exposure. Melissa and Lou bond over their disappointment in their parents. M.O.D.O.K. and Jodie have sex when he goes to apologize, and it is revealed who exactly was behind her publicist’s actions.

Bill joins the military group formed by Ethan, Dominic and Michael. The three men hold a young alien hostage, Isla. Catherine, Sophia and Nathan continue to search for Bill. Adina, and the aliens also set out to find Bill. Chloe accuses the blow when she realizes that Sacha killed Ash. She suggests to her increasingly unstable son to run away with her.

At the university, Sophia watches the videos recorded by Dylan, a young man they found dead, while Catherine focuses on the algorithms he left behind and which decipher the behavior of robots. Thanks to Bill's intervention, Isla manages to flee and join her family.

Emily agrees to help Bill test her for the virus, but soon experiences serious side effects. Sacha, who has secretly followed the group to stay close to Emily, tries to remove her from the group. For their part, Catherine, Sophia and Nathan set out again in search of Bill Ward.

Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. When Devon discovers that his VIP patient has a life-threatening brain condition, the doctors ban together to perform a risky surgery. Meanwhile, Mina discovers that Adaku has a dangerous heart condition that puts her and the baby at risk, and Kyle forms a personal relationship with a patient.

On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. When Bell discovers that Cain is keeping braindead patients alive in order to boost his survival rates and add to Red Rock's profits, he decides to take matters into his own hands. Meanwhile, Adaku goes into early labor, causing a strain on her heart and Mina is left in doubt over how to best handle her care.

After being terminated from Chastain, Conrad has difficulty figuring out his next step and distracts himself by accompanying a patient on a zero-gravity adventure. In his first move as the new Chief of Surgery, Cain puts the doctors on a commission-based pay system, which causes Devon’s new intern to agree to a procedure before weighing the risks. Meanwhile, Mina struggles with taking care of Adaku’s baby and Bell’s supplement company get its big break.

Dr. Addison Forbes Montgomery returns and graces the Grey Sloan halls with her experience and expertise as she attempts to help Richard teach the newest crop of residents. Meredith has a decision to make; Link confides in Teddy.

Richard recruits Meredith and Bailey to help him launch a new program. Addison's patient has complications from a procedure. Jo helps a woman who goes into premature labor.

The doctors spring into action after an explosion rocks Seattle, with the incoming trauma hitting close to home. In Minnesota, Meredith and Amelia meet up with a familiar face who assists in their study.

Just when Ryan agrees to talk it out with his dad, Greg Tanner makes an unexpected visit to Station 19, leaving Ryan and others confused. In an effort to connect with his crew, Captain Sullivan enlists the help of an unlikely source for some bonding tips.

As the team gathers for a Friendsgiving celebration at Dean's, a violent windstorm touches down in Seattle. As the storm picks up speed, creating dangerous fire conditions, the crew must put the festivities on hold and report for duty, leaving some of them in a life-threatening situation.

Five years have passed since Katherine shot her ex-husband as Susan, Lynette, Bree and Gaby stood together in solidarity to protect her. Susan tries to hide her relationship with a new man; Gaby questions her abilities as a mom; Bree is on the verge of publishing her own cookbook as business partner, Katherine, grows envious; Lynette catches her teenaged twins spearheading illegal activities; and Edie returns to Wisteria Lane in jaw-dropping fashion with a new man in tow.

Secrets come out in the open, while others continue to unfold: Lynette discovers her son, Porter, has a softer side, which she finds endearing; Gaby amusingly attempts to mask her demise in social stature; and the time has come for the men in Susan's life to meet. Meanwhile Bree begins to feel the pressures of balancing marriage and a career, Edie is reminded just how hostile the neighbors on Wisteria Lane can be, and a suspicious Mrs. McCluskey enlists Katherine's help to uncover more about their new neighbor, Dave.

It's Thanksgiving and while Meredith faces travel complications, due to the weather, Nick steps in to help – in more ways than one. Richard and Bailey seek out emergency surgeries; Amelia and Link reconnect.

Dr. Hamilton takes his frustrations out on Meredith, so Nick gives her a chance to blow off steam by scrubbing in on a surgery. Back in Seattle, Link and Jo take their kids to a fairytale theater performance that goes wrong. Bailey and Dr. Lin attend a recruitment fair in hopes of attracting more doctors to Grey Sloan but find themselves ill-prepared.

With Chastain on the verge of shutting down due to the sale by Red Rock, Conrad tries a last-ditch effort to save the hospital and the doctors plan for their next career moves. Meanwhile, on their last day, the whole staff must work together to save Nic’s life after she is injured by a deranged patient.

There are bullies among the old and young on "Desperate Housewives." Bree's estranged daughter, Danielle, returns to Wisteria Lane and is met with a deluge of criticism; Gaby and Susan find themselves embroiled in a catfight brought on by an altercation between their kids; to her chagrin, Lynette comes home to find Tom and Dave have formed a garage band after she told him to get rid of his old things; and Katherine and Mrs. McCluskey invite Edie to lunch to press her for more information on Dave.

Jealousy rears its ugly head on "Desperate Housewives." Bree's new cookbook and entrepreneurial success has the women of Wisteria Lane feeling envious; Lynette's longing for a taste of her breadwinning days as an ad-exec leads her to lend an unsolicited hand to Bree's marketing plan; and MJ's drawing of a family portrait has left Mike feeling like he's not a presence in his son's life. Meanwhile, Gaby hatches a plan to have more sex with Carlos, Susan teaches a reluctant MJ how to fall, and Dave's motives for moving to the neighborhood continue to take shape.

A rich investment fund manager, Gerry Roberts, stands trial for defrauding a billion dollars, but he's kidnapped out of the court. A protestor outside the courthouse is run over and killed, and a video surfaces of Gerry being killed but, is it real?

A schizophrenic girl at a mental institution is murdered. Megan and Tommy interview a young patient who seems sane and lucid, she tells them she saw the killer climb down from a heating vent in the ceiling, but he meant to kill her, not the victim.

A plane crashes in Philadelphia due to a gunman opening fire while aloft. The crash hits the city's main power grid, Megan must conduct autopsies on the victims during frequent blackouts, but then one of the bodies goes missing.

Carr needs help.

The night is full of surprises on "Desperate Housewives" as we learn what has transpired on Wisteria Lane in the past five years. Driven by a hidden agenda, Dave convinces Susan to throw Mrs. McCluskey a surprise party for her 70th birthday; Jackson wants to take his relationship with Susan to the next level; Gaby's concerned she might be pregnant; Tom tells Lynette he's sold the pizzeria; a startling reason for the bond between Bree and Katherine is revealed; and an outraged Mrs. McCluskey has the entire neighborhood questioning her sanity.

"Hell hath no fury like a woman scorned," on "Desperate Housewives." Gaby is over the moon when Carlos' client makes them an offer they can't refuse, but a startling discovery leaves her second guessing; Lynette grows suspicious that Tom is cheating on her; and after breaking up with Jackson, Susan tries to surprise him, only to find the surprise is on her. Meanwhile, the bond between Bree and Katherine grows, and Mrs. McCluskey enlists the help of her sister to dig up dirt on Dave.

A high school baseball pitcher Justin finds that he is haunted by the former baseball star pitcher. The ghost is out for revenge on the coach who he blames for his death.

A rich investment fund manager, Gerry Roberts, stands trial for defrauding a billion dollars, but he's kidnapped out of the court. A protestor outside the courthouse is run over and killed, and a video surfaces of Gerry being killed but, is it real?

The Grey Sloan Memorial doctors grapple with the aftermath of the car crash that involved some of their own. Meredith works to save Dr. Hamilton's life; Levi is impacted from his latest loss.

Schmitt must face the Morbidity and Mortality Conference. Meredith convinces Nick to scrub in on a surgery in Seattle. Jo faces her feelings.

Meredith, Amelia and the team prepare for Dr. Hamilton's long-awaited groundbreaking surgery while Bailey receives an unexpected offer. Owen's impatience makes him a difficult physical therapy patient, forcing Link to intervene.